Cialis vs Viagra: Which ED Medication Works Better for You?

When it comes to treating erectile dysfunction, Cialis, a brand name for tadalafil, is a long-acting PDE5 inhibitor used to improve blood flow to the penis. Also known as tadalafil, it’s the go-to for men who want flexibility without timing every activity around a pill. Viagra, the original brand of sildenafil, was the first widely successful ED treatment and remains a top choice for fast, reliable results. Also known as sildenafil, it kicks in quicker but doesn’t last as long. Both are PDE5 inhibitors, meaning they help relax blood vessels so more blood can flow into the penis during arousal. But that’s where the similarities end.

Here’s the real difference: Cialis can last up to 36 hours. That means you can take it Sunday night and still be ready Wednesday morning—no need to plan ahead. Viagra works in about 30 to 60 minutes and wears off in 4 to 5 hours. If you’re spontaneous, Cialis gives you breathing room. If you prefer knowing exactly when it’ll work, Viagra gives you control. Side effects are similar—headache, flushing, upset stomach—but some users report less back pain with Viagra and less muscle aches with Cialis. Dosage matters too: Cialis comes in daily low-dose options for ongoing use, while Viagra is taken as needed. And price? Generic tadalafil is often cheaper than generic sildenafil, especially when bought in bulk.

Neither pill works without sexual stimulation. Neither fixes underlying causes like diabetes, nerve damage, or low testosterone. And if you’re on nitrates for heart issues, you can’t take either—serious drops in blood pressure can happen. Most men try one, then switch if it doesn’t fit their life. The best choice isn’t about which is stronger—it’s about which matches your rhythm.

Below, you’ll find real comparisons between Cialis and Viagra, along with other ED meds like Levitra and Stendra. We break down how long each lasts, how fast they kick in, what they cost, and which ones come with fewer side effects. You’ll also see how they stack up against natural options and combo packs. No fluff. Just what works—and what doesn’t—for real people.