ED Medication Comparison: Cialis, Viagra, Levitra & More Side by Side

When it comes to treating erectile dysfunction, ED medication, prescription drugs that help men achieve and maintain an erection by increasing blood flow to the penis. Also known as PDE5 inhibitors, these medications are among the most widely used treatments for ED worldwide. But not all ED meds work the same way—or for the same people. What works for one man might not work for another, and the differences go far beyond brand names.

Cialis, the brand name for tadalafil, known for its long duration and flexibility in dosing can last up to 36 hours, which is why some call it the "weekend pill." Viagra, the original ED drug, also known as sildenafil, takes effect faster but wears off sooner, usually within 4 to 5 hours. Then there’s Levitra, the trade name for vardenafil, which works well for men with diabetes or after prostate surgery. Each has its own onset time, side effect profile, and how it reacts with food or alcohol. And let’s not forget the newer options like Stendra, avanafil, which starts working in as little as 15 minutes, or the generic versions of these drugs that can cut costs by 80%.

Choosing the right ED medication isn’t just about which one works—it’s about which one fits your lifestyle. Do you need something you can take on a whim? Then speed matters. Do you want to avoid frequent dosing? Then longer duration is key. Are you on other meds, like nitrates for heart issues? Then some options are off the table. And if cost is a concern, generic sildenafil might be your best bet—just make sure you’re buying from a trusted source.

The posts below break down each of these medications side by side. You’ll find real comparisons: how long they last, how fast they kick in, what side effects you’re likely to face, and which ones work best with certain health conditions. No fluff. No marketing. Just clear, honest details from people who’ve tried them—and from the data that backs them up.