Skelaxin vs Flexeril: Which Muscle Relaxant Works Better for You?

When your muscles lock up from injury or strain, Skelaxin, a muscle relaxant with the generic name metaxalone. Also known as metaxalone, it works by calming nerve signals in the brain that cause muscle tightness. Flexeril, a muscle relaxant with the generic name cyclobenzaprine. Also known as cyclobenzaprine, it acts more directly on the central nervous system to reduce muscle spasms. Both are prescribed for short-term relief of acute muscle pain, but they’re not the same drug—and knowing the difference can save you from unnecessary side effects or ineffective treatment.

Skelaxin is often chosen when you need relief without heavy drowsiness. It’s less likely to make you sleepy than Flexeril, which is why some people pick it for daytime use. Flexeril, on the other hand, works faster and can be stronger for severe spasms, but it often causes dizziness, dry mouth, or fatigue. If you’re driving, working, or caring for kids, that matters. Skelaxin doesn’t interact as much with other meds, while Flexeril can clash with antidepressants, alcohol, or sedatives. If you’re already taking something for anxiety, depression, or sleep, your doctor needs to know before prescribing Flexeril.

Neither drug fixes the root cause of your muscle pain—like a bad back or overworked shoulder. They just give you breathing room while your body heals. That’s why they’re usually paired with rest, physical therapy, or stretching. Skelaxin is often used for sports injuries or sudden back strains. Flexeril shows up more often in cases of chronic neck or lower back tension. Neither is meant for long-term use. Most doctors limit prescriptions to 2–3 weeks because tolerance builds fast, and side effects pile up.

If you’ve tried one and it didn’t work—or made you feel worse—you’re not alone. Many people switch between Skelaxin and Flexeril before finding the right fit. Some respond better to one because of their metabolism, age, or other health conditions. Older adults often do better with Skelaxin because Flexeril can increase fall risk. People with liver issues need to be careful with both, but Flexeril is processed more heavily by the liver, so it’s riskier there.

Below, you’ll find real comparisons from people who’ve used both. We break down side effects, dosing, cost, and how each stacks up against other muscle relaxants. No fluff. Just what works, what doesn’t, and what to ask your doctor before you start.